SNP Panel Analysis of Ancestry Inference in East Asian Populations.
10.12116/j.issn.1004-5619.2020.500713
- Author:
Zhen Jun JIA
1
;
Chun Fang GAO
1
;
Zun Lei QIAN
1
;
Zhuo LIU
1
;
Qiang TANG
2
;
Mei Qing YUAN
3
Author Information
1. College of Criminal Investigation, People's Public Security University of China, Beijing 100038, China.
2. College of Police Physical and Tactical Training, People's Public Security University of China, Beijing 100038, China.
3. Key Laboratory of Forensic Genetics, Institute of Forensic Science, Ministry of Public Security, Beijing 100038, China.
- Publication Type:Journal Article
- Keywords:
forensic genetics;
single nucleotide polymorphism （SNP）;
principal component analysis （PCA）;
heatmap;
ancestry inference;
East Asian population
- MeSH:
Asian People/genetics*;
Gene Frequency;
Genetics, Population;
Humans;
Polymorphism, Single Nucleotide;
Principal Component Analysis
- From:
Journal of Forensic Medicine
2021;37(4):539-545
- CountryChina
- Language:Chinese
-
Abstract:
Objective To develop an SNP Panel for East Asian population, which has a high individual identification rate and the capability of ancestry analysis. Methods The 55 SNP Panel by Professor KIDD of Yale University and the 128 SNP Panel by Professor SELDIN of Davis School of California University, 170 SNP Panel in total was used as the basis and its test data in the East Asian population was collected. The genetic parameters of SNP loci were calculated and combined with the results of heatmap analysis to screen SNP loci suitable for East Asian population. Some Tibetan and Han samples were tested. The possibility of using the SNP loci in ancestry inference was analyzed by means of STRUCTURE analysis, principal component analysis and heatmap analysis. Results A Panel with 45 SNPs （45 SNP Panel） was screened out, and the average genetic parameters of each SNP were better than 170 SNP Panel, with the same ancestry analysis and inference ability. Conclusion In terms of ancestry inference information, the 45 SNP Panel can completely replace the 170 SNP Panel and achieve the same ancestry analysis and inference ability. In genetic parameters, 45 SNP Panel is better than 170 SNP Panel in the East Asian population, which shows its important potential forensic application value.
