Clinical effect of Kangfuxin solution combined with lidocaine and gentamicin in the treatment of oral ulcer
10.12206/j.issn.2097-2024.202207080
- VernacularTitle:康复新液联合利多卡因及庆大霉素治疗口腔溃疡的临床疗效观察
- Author:
Ling ZHAO
1
;
Yanan WU
1
;
Mingyuan XU
1
Author Information
1. Department of Stomatology, Tongzhou Maternal and Child Health Hospital of Beijing, Beijing 101101, China.
- Keywords:
Inflammatory factor;
Kangfuxin solution;
Lidocaine;
Gentamicin;
Oral ulcer
- From:
Journal of Pharmaceutical Practice
2023;41(8):515-518
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of Kangfuxin solution combined with lidocaine and gentamicin in the treatment of oral ulcers. Method A total of 120 patients with oral ulcer admitted to Tongzhou District Maternity and Child Health Care Hospital of Beijing from May 2019 to July 2021 were selected and divided into observation group and control group randomly. 58 patients were treated with lidocaine as a control group and 62 patients in the observation group were treated with Kangfuxin solution combined with lidocaine and gentamicin. The clinical efficacy, including oral ulcer condition, visual analogue scale (VAS score) after 3d and 5d of treatment, inflammatory factor levels and adverse reactions were observed and compared between the two groups before and after treatment. Results The overall effective rate of the treatment group (95.12%) was higher than that of the control group (74.36%) and the difference was statistically significant (P<0.05). The ulcer area, ulcer healing time, and chewing improvement period were remarkably reduced compared with those in the control group (P<0.05). The VAS scores after 3d and 5d of treatment, the levels of tumor necrosis factor-α (TNF-α), C-reactive protein (CRP) and interleukin-6 (IL-6) between the two groups were statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions (3.22%) between the observation group and the control group (6.90%) (P>0.05). Conclusion Kangfuxin solution combined with lidocaine and gentamicin showed better curative effect on oral ulcer. This treatment regimen could effectively ameliorate various clinical symptoms of patients with oral ulcer, reduce patient pain and downregulate the levels of inflammatory factors, and help patients recover with high safety profile.
