A mathematic equation derived from host-pathogen interactions elucidates the significance of integrating modern medicine with traditional Chinese medicine to treat infectious diseases.
10.1016/j.joim.2023.06.004
- Author:
Jianjun SUN
1
Author Information
1. Department of Biological Sciences, Border Biomedical Research Center, University of Texas at El Paso, TX 79968, USA. Electronic address: jsun@utep.edu.
- Publication Type:Journal Article
- Keywords:
HPI-Equation;
Host-based medicine;
Host-pathogen interactions;
Immune response;
Pathogen-targeted medicine;
Self-healing power;
Tolerance;
Traditional Chinese medicine
- MeSH:
Animals;
Medicine, Chinese Traditional;
Communicable Diseases/drug therapy*;
Mathematics;
Host-Pathogen Interactions;
Drugs, Chinese Herbal/therapeutic use*
- From:
Journal of Integrative Medicine
2023;21(4):324-331
- CountryChina
- Language:English
-
Abstract:
The prognosis of infectious diseases is determined by host-pathogen interactions. Control of pathogens has been the central dogma of treating infectious diseases in modern medicine, but the pathogen-directed medicine is facing significant challenges, including a lack of effective antimicrobials for newly emerging pathogens, pathogen drug resistance, and drug side effects. Here, a mathematic equation (termed equation of host-pathogen interactions, HPI-Equation) is developed to dissect the key variables of host-pathogen interactions. It shows that control of pathogens does not necessarily lead to host recovery. Instead, a combination of promoting a host's power of self-healing and balancing immune responses provides the best benefit for host. Moreover, the HPI-Equation elucidates the scientific basis of traditional Chinese medicine (TCM), a host-based medicine that treats infectious diseases by promoting self-healing power and balancing immune responses. The importance of self-healing power elucidated in the HPI-Equation is confirmed by recent studies that the tolerance mechanism, which is discovered in plants and animals and conceptually similar to self-healing power, improves host survival without directly attacking pathogens. In summary, the HPI-Equation describes host-pathogen interactions with mathematical logic and precision; it translates the ancient wisdoms of TCM into apprehensible modern sciences and opens a new venue for integrating TCM and modern medicine for a future medicine. Sun J. A mathematic equation derived from host-pathogen interactions elucidates the significance of integrating modern medicine with traditional Chinese medicine to treat infectious diseases. J Integr Med. 2023; 21(4):324-331.
