Mechanism Study on Chinese Medicine in Treatment of Nodular Goiter.
10.1007/s11655-022-3724-3
- Author:
Chang-Lin WANG
1
;
Ming-Zhou GAO
1
;
Xiang-Ju GAO
1
;
Xiang-Yu MU
1
;
Jie-Qiong WANG
2
;
Dong-Mei GAO
1
;
Ming-Qi QIAO
3
Author Information
1. School of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China.
2. Research and Innovation Team of Emotional Diseases and Syndromes of Shandong University of Traditional Chinese Medicine, Jinan, 250355, China.
3. School of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China. qmingqi@sdutcm.com.
- Publication Type:Review
- Keywords:
Chinese medicine;
mechanism;
nodular goiter;
pharmacology;
review
- MeSH:
Humans;
Goiter, Nodular/metabolism*;
Medicine, Chinese Traditional;
Thyroid Neoplasms;
Apoptosis;
China
- From:
Chinese journal of integrative medicine
2023;29(6):566-576
- CountryChina
- Language:English
-
Abstract:
Nodular goiter has become increasingly prevalent in recent years. Clinically, there has been a burgeoning interest in nodular goiter due to the risk of progression to thyroid cancer. This review aims to provide a comprehensive summary of the mechanisms underlying the therapeutic effect of Chinese medicine (CM) in nodular goiter. Articles were systematically retrieved from databases, including PubMed, Web of Science and China National Knowledge Infrastructure. New evidence showed that CM exhibited multi-pathway and multi-target characteristics in the treatment of nodular goiter, involving hypothalamus-pituitary-thyroid axis, oxidative stress, blood rheology, cell proliferation, apoptosis, and autophagy, especially inhibition of cell proliferation and promotion of cell apoptosis, involving multiple signal pathways and a variety of cytokines. This review provides a scientific basis for the therapeutic use of CM against nodular goiter. Nonetheless, future studies are warranted to identify more regulatory genes and pathways to provide new approaches for the treatment of nodular goiter.
