Platelet Transfusion Strategies for MASPAT-Matched Platelet Transfusion Failed Patient with Allogeneic Hematopoietic Stem Cell Transplantation.
10.19746/j.cnki.issn.1009-2137.2023.03.034
- Author:
Lu YANG
1
;
Chun-Ya MA
2
;
Li-Hui FU
2
;
Sheng-Fei TAI
2
;
Ming-Zi MA
1
;
Xiao-Long ZHONG
2
;
Bin FAN
2
;
Xiao-Xing WANG
2
;
De-Qing WANG
3
;
Yang YU
4
,
5
Author Information
1. Medical School of Chinese PLA; Department of Transfusion Medicine, The First Medical Centre, Chinese PLA General Hospital, Beijing 100853, China.
2. Department of Transfusion Medicine, The First Medical Centre, Chinese PLA General Hospital, Beijing 100853, China.
3. Department of Transfusion Medicine, The First Medical Centre, Chinese PLA General Hospital, Beijing 100853, China.E-mail: deqingw@vip.sina.com.
4. Department of Transfusion Medicine, The First Medical Centre, Chinese PLA General Hospital, Beijing 100853, China.E-mail: yuyangpla301@
5. com.
- Publication Type:Journal Article
- Keywords:
donor-specific HLA antibody;
ineffective platelet transfusion;
missed detection of antibody;
monoclonal antibody solid phase platelet antibody test;
primary implantation failure
- MeSH:
Female;
Humans;
Adult;
Platelet Transfusion;
Antibodies, Monoclonal;
Retrospective Studies;
HLA Antigens;
Hematopoietic Stem Cell Transplantation
- From:
Journal of Experimental Hematology
2023;31(3):850-854
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the causes of ineffectiveness of platelet transfusion with monoclonal antibody solid phase platelet antibody test (MASPAT) matching in patients with allogeneic hematopoietic stem cell transplantation and explore the strategies of platelet transfusion.
METHODS:A case of donor-specific HLA antibodies (DSA) induced by transfusion which ultimately resulted in transplantation failure and ineffective platelet transfusion with MASPAT matching was selected, and the causes of ineffective platelet transfusion and platelet transfusion strategy were retrospectively analyzed.
RESULTS:The 32-year-old female patient was diagnosed as acute myeloid leukemia (high risk) in another hospital with the main symptoms of fever and leukopenia, who should be admitted for hematopoietic stem cell transplantation after remission by chemotherapy. In the course of chemotherapy, DSA was generated due to platelet transfusion, and had HLA gene loci incompatible with the donor of the first transplant, leading to the failure of the first transplant. The patient received platelet transfusion for several times before and after transplantation, and the results showed that the effective rate of MASPAT matched platelet transfusion was only 35.3%. Further analysis showed that the reason for the ineffective platelet transfusion was due to the missed detection of antibodies by MASPAT method. During the second hematopoietic stem cell transplantation, the DSA-negative donor was selected, and the matching platelets but ineffective transfusion during the primary transplantation were avoided. Finally, the patient was successfully transplanted and discharged from hospital.
CONCLUSIONS:DSA can cause graft failure or render the graft ineffective. For the platelet transfusion of patients with DSA, the platelet transfusion strategy with matching type only using MASPAT method will miss the detection of antibodies, resulting in invalid platelet transfusion.
