Risk Factors and Prognosis of Cardiovascular Damage in Hypereosinophilia.
10.19746/j.cnki.issn.1009-2137.2023.03.028
- Author:
Wen-Jie ZHANG
1
;
Qi-Ke ZHANG
2
,
3
;
Xiao-Fang WEI
1
;
You-Fan FENG
1
;
Yang CHEN
1
Author Information
1. Department of Hematology, Gansu Provincial Hospital, Lanzhou 730000, Gansu Province, China.
2. Department of Hematology, Gansu Provincial Hospital, Lanzhou 730000, Gansu Province, China. E-mail: zqk05@
3. com.
- Publication Type:Journal Article
- Keywords:
event-free survival;
cardiovascular damage;
hypereosinophilia;
overall survival;
prognosis
- MeSH:
Male;
Female;
Humans;
Middle Aged;
Aged;
Interleukin-4;
Biomarkers;
Retrospective Studies;
Interleukin-5;
Prognosis;
Risk Factors;
Eosinophilia;
Peptide Fragments;
Natriuretic Peptide, Brain
- From:
Journal of Experimental Hematology
2023;31(3):810-815
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the risk factors and prognosis of cardiovascular damage in hypereosinophilia (HE).
METHODS:The clinical data of 62 patients with HE in Gansu Provincial Hospital from January 2015 to December 2020 were retrospectively analyzed, including clinical characteristics and laboratory indicators, and the influencing factors of survival and prognosis were also analyzed.
RESULTS:In this study, there were 34 males and 28 females, with a median age of 53.5 (20-79) years, 35 patients without cardiovascular damage, 27 patients with cardiovascular damage, including 22 patients with abnormal electrocardiogram (ECG) (81.5%), 18 patients with abnormal echocardiography (ECHO) (66.7%), 9 patients with single ECG abnormality, 5 patients with single ECHO abnormality, and other 13 patients with multiple abnormalities. In cardiovascular damage group, peripheral white blood cell count, absolute value of eosinophils, troponin T (TNT), N-terminal pro-B-type natriuretic peptide (NT-proBNP), interleukin (IL)-4 and IL-5 levels at initial diagnosis were significantly higher than those in the non-cardiovascular damage group (P <0.01), while hemoglobin, IL-2 and interferon-γ levels were significantly lower (P <0.01). There were no significant differences in age, sex, course of disease, etiological classification, platelet count, serum creatine kinase, serum creatine kinase isoenzyme and lactate dehydrogenase between the two groups (P >0.05). The 5-year overal survival rate of patients with cardiovascular damage was 88.9%, and that of patients without cardiovascular damage was 100%, the difference was statistically significant (P =0.012). The 5-year event-free survival (EFS) rate of patients with cardiovascular damage was 59.3%, and the median time was 37 (21-52) months, while that of patients without cardiovascular damage was 80%, and the median time was 63 (51-74) months (P =0.002). Age (>60 years old), course of disease (>24 months), NT-proBNP (>3 000 pg/ml), TNT (>100 ng/L), elevated IL-4 and IL-5 were associated with EFS shortening in patients with cardiovascular damage, which were independent risk factors for EFS.
CONCLUSION:The EFS rate in HE patients without cardiovascular damage is significantly higher than patients with cardiovascular damage. Age, course of disease, NT-proBNP, TNT, IL-4 and IL-5 are independent risk factors affecting EFS of patients with cardiovascular damage.
