Role of TGF-β/Smad signaling pathway in diabetic kidney disease and research progress of traditional Chinese medicine intervention.
10.19540/j.cnki.cjcmm.20221114.401
- Author:
Yan-Xu CHEN
1
;
Xiao-Xue JIANG
1
;
Qin-Yuan ZHANG
1
;
Chang-Qing XU
1
;
Yao-Mu HU
1
;
Cai-Yun JIN
1
;
Bo-Ling ZHANG
1
;
Yao-Qin FU
1
;
Zhi-Sheng JIN
2
Author Information
1. Gansu University of Chinese Medicine Lanzhou 730000, China.
2. Gansu University of Chinese Medicine Lanzhou 730000, China Affiliated Hospital of Gansu University of Chinese Medicine Lanzhou 730000, China.
- Publication Type:Journal Article
- Keywords:
TGF-β/Smad signaling pathway;
diabetic kidney disease;
mechanism;
traditional Chinese medicine;
traditional Chinese medicine compound prescription;
traditional Chinese medicine extract
- MeSH:
Humans;
Diabetic Nephropathies/genetics*;
Medicine, Chinese Traditional;
Kidney/pathology*;
Transforming Growth Factor beta/metabolism*;
Signal Transduction;
Epithelial-Mesenchymal Transition;
Smad Proteins/metabolism*;
Transforming Growth Factor beta1/metabolism*;
Diabetes Mellitus/genetics*
- From:
China Journal of Chinese Materia Medica
2023;48(10):2630-2638
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic kidney disease is an important microvascular complication of diabetes and the leading cause of end-stage renal disease. Its pathological characteristics mainly include epithelial mesenchymal transition(EMT) in glomerulus, podocyte apoptosis and autophagy, and damage of glomerular filtration barrier. Transforming growth factor-β(TGF-β)/Smad signaling pathway is specifically regulated by a variety of mechanisms, and is a classic pathway involved in physiological activities such as apoptosis, proliferation and differentiation. At present, many studies have found that TGF-β/Smad signaling pathway plays a key role in the pathogenesis of diabetic kidney disease. Traditional Chinese medicine has significant advantages in the treatment of diabetic kidney disease for its multi-component, multi-target and multi-pathway characteristics, and some traditional Chinese medicine extracts, traditional Chinese medicines and traditional Chinese medicine compound prescription improve the renal injury of diabetic kidney disease by regulating TGF-β/Smad signaling pathway. This study clarified the mechanism of TGF-β/Smad signaling pathway in diabetic kidney disease by expounding the relationship between the key targets of the pathway and diabetic kidney disease, and summarized the research progress of traditional Chinese medicine in the treatment of diabetic kidney disease by interfering with TGF-β/Smad signaling pathway in recent years, to provide reference for drug research and clinical treatment of diabetic kidney disease in the future.
