Oxidative stress status and its correlation with UACR and Uβ2-MG levels in patients with diabetic nephropathy
10.3969/j.issn.1006-2483.2023.04.020
- VernacularTitle:糖尿病肾病患者氧化应激状态及与UACR和Uβ2-MG的相关性
- Author:
Yang LIU
1
;
Xiuli HUANG
1
;
Yan WU
1
Author Information
1. Department of Endocrinology and Metabolism , Suining Central Hospital , Suining , Sichuan 629000 , China
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathy;
Oxidative stress status;
UACR and Uβ2-MG levels
- From:
Journal of Public Health and Preventive Medicine
2023;34(4):85-88
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze oxidative stress status and its correlation with urinary albumin creatinine ratio (UACR) and urinary β2 microglobulin (Uβ2-MG) in patients with diabetic nephropathy (DN), and to provide a theoretical basis for clinical evaluation of oxidative stress status in DN patients. Methods A total of 382 DN patients admitted to our hospital from January 2020 to December 2021 were selected. According to the 24h urinary microalbumin excretion rate (24h UAER), the patients were divided into mild renal injury group (20µg/min <24h UAER<200µg/min, n=233) and severe renal injury group (24h UAER≥200µg/min, n=149). Oxidative stress indicators as well as UACR and Uβ2-MG levels in all subjects were determined. Spearman correlation was used to analyze the correlation between oxidative stress status and the levels of UACR and Uβ2-MG in DN patients. The combined ROC curve of UACR and Uβ2-MG was used to predict the efficacy of oxidative stress status in DN patients. Results The level of SOD in the severe renal injury group was significantly lower than that in the mild renal injury group (P<0.05). The serum MDA level in the severe renal injury group was significantly higher than that in the mild renal injury group (P<0.05). The levels of UACR and Uβ2-MG in the severe renal injury group were significantly higher than those in the mild renal injury group (P<0.05). Spearman correlation analysis showed that SOD level was positively correlated with UACR and Uβ2-MG levels in DN patients (r=-0.462, 0.413, P<0.05). The serum MDA level was negatively correlated with UACR and Uβ2-MG levels in DN patients (r=-0.438, -0.459, P<0.05). The ROC curve analysis showed that the combined AUC of UACR and Uβ2-MG to predict the oxidative stress status of DN patients was 0.689, the sensitivity was 79.84%, and the specificity was 83.45%. Conclusion Oxidative stress in DN patients can accelerate the pathological progression of nephropathy. The oxidative stress status is closely related to the levels of UACR and Uβ2-MG, which can be used to judge the oxidative stress of the body and prevent the pathological progression of nephropathy in DN patients.
