Taking the mechanism of glucose catabolism disorder in depression as an example to explore the research ideas and strategies of stable isotope tracer metabolomics
10.16438/j.0513-4870.2022-1286
- VernacularTitle:以抑郁症葡萄糖分解代谢障碍机制解析为例探究稳定同位素示踪代谢组学的研究思路与策略
- Author:
Jun-sheng TIAN
1
;
Yun-hao ZHAO
1
;
Ting LING-HU
1
;
Wen-ze WU
1
;
Shao-bo LIU
1
;
Xian-xian WANG
1
;
Xue-mei QIN
1
Author Information
1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China; Shanxi Key Laboratory of Active Constituents Research and Utilization of TCM, Taiyuan 030006, China
- Publication Type:Research Article
- Keywords:
stable isotope tracer metabolomics;
epression;
energy metabolism;
glucose catabolism disorder;
research ideas and strategy
- From:
Acta Pharmaceutica Sinica
2023;58(7):1725-1731
- CountryChina
- Language:Chinese
-
Abstract:
Stable isotope tracer metabolomics tracks and analyzes the whole metabolic process of the body through the tracer atoms, which belongs to the frontier technology in the field of biomedicine. This technology is of great significance and value for explaining the pathogenesis of diseases, finding biomarkers of diseases and drug action targets. Taking the mechanism of glucose catabolism disorder in depression as an example, this paper systematically expounds the stable isotope tracer metabolomics technology and its application. The research idea of stable isotope tracer metabolomics based on unmarked metabolomics was put forward, and the research strategy of biological significance interpretation from four dimensions of metabolite isotope abundance, key metabolic enzymes, metabolic flow direction and metabolite flow was given, which broke through the bottleneck of stable isotope tracer metabolomics research technology based on overall animal experiment, and provided scientific basis for the promotion and application of this technology.
