Research status of machine perfusion of heart
10.3969/j.issn.1674-7445.2023.04.002
- VernacularTitle:心脏机械灌注技术的研究现状
- Author:
Jinping LIU
1
;
Wei WANG
Author Information
1. Department of Cardiovascular Surgery, Zhongnan Hospital of Wuhan University, Hubei Provincial Engineering Research Center of Minimally Invasive Cardiovascular Surgery, Wuhan Clinical Research Center for Minimally Invasive Treatment of Structural Heart Disease, Wuhan 430071, China
- Publication Type:Research Article
- Keywords:
Heart transplantation;
Donor heart preservation;
Ischemia-reperfusion injury;
Static cold storage;
Machine perfusion;
Expanded criteria donor;
Donation after cardiac death (DCD);
Donation after brain death (DBD)
- From:
Organ Transplantation
2023;14(4):479-
- CountryChina
- Language:Chinese
-
Abstract:
High-quality donor heart is the prerequisite and fundamental guarantee for successful heart transplantation. Reasonable donor heart preservation technique plays a key role in improving the quality of donor heart and the prognosis of heart transplantation. Static cold storage (SCS) is currently the standard preservation technique for cardiac allograft. However, it is prone to cause severe cold ischemia injury to the donor heart, and it is impossible to evaluate heart function during SCS. As an important emerging technique of organ preservation, machine perfusion better matches with physiological conditions compared with SCS, which may remove metabolic wastes and provide basic substances for metabolic needs during organ preservation, prolong the preservation time and improve the preservation effect to a certain extent. Besides, it may also effectively evaluate organ function and improve clinical prognosis of heart transplantation. Meantime, it can also repair organ damage, significantly optimize organ quality and improve the utilization rate of donor organs. In this article, research status of machine perfusion of donor heart was reviewed.
