ErbB4 Regulates the Timely Development of Late Fetal Lung Function and Structure
- VernacularTitle: ErbB4 Regulates the Timely Development of Late Fetal Lung Function and Structure
- Author:
Erkhembulgan PUREVDORJ
;
Washa LIU
;
Katja ZSCHEPPANG
;
Dietlinde von Mayersbach
;
Jan BEHRENS
;
Maria-Jantje BRINKHAUS
;
Heber C. Nielsen
;
Andreas SCHMIEDL
;
Christiane E.L. Dammann u
- Publication Type:journal article
- Keywords:
transgenic mice, pulmonary,surfactant, lung morphogenesis.inflammation
- From:Innovation
2009;6(1):51-58
- CountryMongolia
- Language:English
-
Abstract:
ErbB4 receptor has an important function in fetal lung cell maturation. Deletion of ErbB4 leads to alveolar simplification and airway hyperreactivity in adult mice. We aimed to study the effects of ErbB4 deletion on the fetal lung. The pulmonary structure, surfactant protein (SP) expression, surfactant synthesis and secretion in fetal ErbB4-deleted IIER4hc*r1 mice were studied at El6, El7, and El8. Morphometry at EIX showed a decrease in the size of saccules in HER4hc"1 lungs. At E17, the structural development of the ErbB4-deleted lungs was delayed, keeping these lungs in the canalicular stage. Expression of SP-B and SP-I) were both decreased at El8 in HER4hc"1 lungs. Surfactant phospholipid synthesis and secretion were both reduced at El8, but at El 7, only synthesis was decreased. Pulmonary ErbB4 deletion results in a structural and functional developmental delay, indicating a crucial regulatory role of F.rbB4 in the timely progression of fetal lung development.
