Current research status of ionizing radiation bleeding syndrome
10.13491/j.issn.1004-714X.2021.04.026
- VernacularTitle:电离辐射出血综合征的研究现状
- Author:
Xinmiao WANG
1
;
Junping WANG
1
;
Xinze RAN
1
Author Information
1. Institute of Combined Injury, Army Military Medical University, State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing 400038 China.
- Publication Type:ExpertComments
- Keywords:
Ionizing Radiation;
Hemorrhage;
Platelet
- From:
Chinese Journal of Radiological Health
2021;30(4):524-528
- CountryChina
- Language:Chinese
-
Abstract:
Bleeding caused by ionizing radiation involves many factors, the mechanism is complicated and the management is difficult. Bleeding is recognized as one of the main causes of death after ionizing radiation. In this paper, we summarize the pathophysiological mechanisms of ionizing radiation bleeding syndrome (IRBS) from the aspects of platelet abnormality, coagulation disorder and vascular damage. Besides, we expound the clinical characteristics of IRBS in terms of the degree, time and site of the bleeding. Combined with experimental results, we put forward ideas and possible approaches for the treatment of IRBS, and the key factor is to promote the recovery of megakaryocytes and rapid platelet production after radiation exposure.
