Progress of researches on antimalarial peptides
10.16250/j.32.1374.2023011
- VernacularTitle:抗疟多肽研究进展
- Author:
Dongying ZHANG
1
;
Xiaoqin HE
1
;
Jun CAO
1
Author Information
1. School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; National Health Commission Key Laboratory on Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu 214064, China
- Publication Type:Journal Article
- Keywords:
Malaria;
Plasmodium;
Antimicrobial peptide;
Antimalarial agent
- From:
Chinese Journal of Schistosomiasis Control
2023;35(2):191-198
- CountryChina
- Language:Chinese
-
Abstract:
Malaria remains a major global public health concern, and nearly half of the global populations are still at risk of malaria infection. However, continuous emergence and spread of drug-resistant malaria parasite strains lead to ineffectiveness of conventional antimalarials. Therefore, development of novel antimalarial agents is of urgent need for malaria elimination. As an important component of the host natural immune defense system, antibacterial peptides provide the first line of defense against pathogenic invasion, and the mechanism of preferentially attacking the cell membrane makes them difficult to develop drug resistance. Antimicrobial peptides are therefore considered as a promising candidate for novel antimalarial agents. This review summarizes the advances in researches on antimicrobial peptides with antimalarial actions and discusses the potential of antimalarial peptides as novel antimalarials.
