Advances in potential drugs for improvement of energy metabolism in heart failure
10.12206/j.issn.2097-2024.202205088
- VernacularTitle:改善心力衰竭能量代谢的潜在药物研究进展
- Author:
Xiaofei SHI
1
;
Yi CHEN
1
;
Feng CHEN
1
;
Kai JING
1
;
Yue GAO
2
;
Xia LIU
1
Author Information
1. School of Pharmacy, Naval Medical University, Shanghai 200433 , China.
2. Clinical Research Center, The First Affiliated Hospital, Naval Medical University, Shanghai 200433, China.
- Keywords:
heart failure;
energy metabolism;
anti-heart failure drugs
- From:
Journal of Pharmaceutical Practice
2023;41(5):284-290
- CountryChina
- Language:Chinese
-
Abstract:
Heart failure (HF) is a global public health problem with high morbidity and mortality. Numerous studies have shown that HF is caused by severe disturbance of energy metabolism, resulting in insufficient cardiac energy supply. This lack of energy could lead to a failure of the heart to pump blood and a failure of energy metabolism in other organs throughout the body. Currently, therapeutics of HF work by reducing heart rate and cardiac preload and afterload, symptomatic treatment, or delaying the progression of the disease. However, drugs targeting heart energy metabolism have not been developed. the main characteristics of cardiac energy metabolism, metabolic changes during HF were summarized and drugs that improve cardiac function through energy metabolism were discussed, which could provide a new research direction for the development and application of drugs in treatment of heart failure.
