Traditional Chinese Medicine Intervenes in Signaling Pathways Associated with CKD-MBD： A Review
10.13422/j.cnki.syfjx.20230590
- VernacularTitle:中医药治疗慢性肾脏疾病矿物质和骨代谢异常相关信号通路研究进展
- Author:
Xingyun GUO
1
;
Ning ZHANG
1
;
Shiyi LIU
1
Author Information
1. Wangjing Hospital of China Academy of Chinese Medical Sciences，Beijing 100102，China
- Publication Type:Journal Article
- Keywords:
chronic kidney disease-mineral and bone disorder （CKD-MBD）;
vascular calcification;
fibroblast growth factor 23/Klotho （FGF23/Klotho） signaling pathway;
Wnt/β-catenin signaling pathway;
receptor activator of nuclear factor κB/receptor activator of nuclear factor κB ligand/osteoprotegerin （RANK/RANKL/OPG） signaling pathway;
traditional Chinese medicine;
Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(12):248-256
- CountryChina
- Language:Chinese
-
Abstract:
Traditional Chinese medicine （TCM） has certain advantages in the treatment of chronic kidney disease-mineral and bone disorder （CKD-MBD）. In recent years， there have been many studies on the treatment of CKD-MBD by Chinese medicinal compounds and monomers. As revealed by literature retrieval， the research on the mechanism of Chinese medicine in intervening in signaling pathways related to CKD-MBD was mainly based on self-made Chinese medicinal compounds， and the action pathways involved fibroblast growth factor 23/Klotho （FGF23/Klotho） signaling pathway， Wnt/β-catenin signaling pathway， receptor activator of nuclear factor-κB/receptor activator of nuclear factor-κB ligand/osteoprotegerin （RANK/RANKL/OPG） system， and other signaling pathways. TCM can improve calcium and phosphorus metabolism and bone metabolism disorder， and regulate inflammatory reaction， oxidative stress， apoptosis， and autophagy by regulating this series of signaling pathways for the treatment of CKD-MBD. This paper introduced the research results of these signaling pathways and the mechanism of TCM in the treatment of CKD-MBD in order to provide ideas and references for the related research of Chinese medicine in the treatment of CKD-MBD.
