Anticancer activity test of ethyl acetate extract of endophytic fungi isolated from soursop leaf (Annona muricata L.)
10.1016/j.apjtm.2017.06.004
- Author:
I. Made ARTIKA
1
;
I. Made HASIM
1
;
Akhmad Endang Zainal HASAN
1
;
Heddy JULISTIONO
2
;
Nurliani BERMAWIE
3
;
Eny Ida RIYANTI
4
Author Information
1. Department of Biochemistry, Faculty of Mathematics and Sciences, Bogor Agricultural University, Darmaga Campus
2. Research Center for Biology, The Indonesian Institute of Sciences (LIPI)
3. Research Institute of Medicinal and Aromatic Plants, Agricultural Research Agency
4. Center for Biotechnology and Genetic Resources of Agriculture, Agricultural Research Agency
- Collective Name:Department of Biochemistry, Faculty of Mathematics and Sciences, Bogor Agricultural University, Darmaga Campus
- Publication Type:Journal Article
- Keywords:
Annona muricata L.;
Anticancer MCF-7;
Endophytic fungi;
Soursop leaf
- From:
Asian Pacific Journal of Tropical Medicine
2017;10(6):566-571
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze anticancer activity of an ethyl acetate extract of endophytic fungi isolated from soursop leaf (Annona muricata L.). Methods Anticancer activity of fungal extracts was determined by observing its toxicity against MCF-7 (Michigan Cancer Foundation-7) cells in vitro by using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay method. At an extract concentration of 100 μg/mL, 4 isolates out of 12 showed high activity against the cancer cell growth. The four isolates were then selected for further IC
