Effect of axial vertical vibration on degeneration of lumbar intervertebral discs in modified bipedal rats: An in-vivo study
10.1016/j.apjtm.2017.07.014
- Author:
Xiao LIANG
1
;
Hao SHEN
1
;
Wei-Dong SHI
1
;
Hao LIU
1
;
Peng YANG
1
;
Zhi-Yong SUN
1
;
Jun LIN
1
;
Hui-Lin YANG
1
;
Shan REN
2
;
Wei JIANG
3
Author Information
1. Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University
2. Intensive Care Unit Department, The First Affiliated Hospital of Medical College, Shihezi University
3. Department of Nephrology, The Affiliated Hospital of Qingdao University
- Publication Type:Journal Article
- Keywords:
Animal model;
Gene expression;
Intervertebral disc;
Vibration
- From:
Asian Pacific Journal of Tropical Medicine
2017;10(7):714-717
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the effects of axial vibrations on gene expression and lumbar intervertebral disc degeneration in vivo. Methods A modified bipedal rat model was established using a brachial plexus rhizotomy approach to imitate human upright posture. The experimental animals were randomly divided into three groups: control, vertical vibration, and whole-body vibration. Gene expression in degeneration of the intervertebral discs was assessed by reverse transcription-quantitative polymerase chain reaction. Results The expression of aggrecan, Col1α1, Col2α1, and decorin were shown to be up-regulated in 14-week-old rats in the vertical vibration and whole-body vibration groups, whereas biglycan and versican expression was down-regulated in 14-week-old rats of the two experimental groups. Furthermore, biglycan and versican expression levels were shown to be lower in the whole-body vibration group than in the vertical vibration group (P < 0.05). Conclusions This in-vivo study demonstrated that vibrations can influence the expression of anabolic genes. Furthermore, whole-body vibrations seem to have a greater effect in this regard than vertical vibrations. A new method is expected to relieve the low back pain of the patients through our research.
