Therapeutic role of Ricinus communis L. and its bioactive compounds in disease prevention and treatment

Waseem ABDUL; Nahid HAJRAH; Jamal SABIR; Saleh AL-GARNI; Meshaal SABIR; Saleh KABLI; Kulvinder SAINI; Roop BORA; Kulvinder SAINI; Roop BORA

Return

Therapeutic role of Ricinus communis L. and its bioactive compounds in disease prevention and treatment

Author: Waseem ABDUL ¹ ; Nahid HAJRAH ¹ ; Jamal SABIR ¹ ; Saleh AL-GARNI ¹ ; Meshaal SABIR ¹ ; Saleh KABLI ¹ ; Kulvinder SAINI ¹ ; Roop BORA ¹ ; Kulvinder SAINI ² ; Roop BORA ²
Author Information

1. Biotechnology Research Group, Department of Biological Sciences, Faculty of Science, King Abdulaziz University
2. Department of Biotechnology, Eternal University
Publication Type:Journal Article
Keywords: Anti-cancer; Bioactive compounds; Ethnomedicine; Molecular targets; Pharmacology; Ricinus communis
From: Asian Pacific Journal of Tropical Medicine 2018;11(3):177-185
CountryChina
Language:Chinese
Abstract: Ricinus communis L. (R. communis), commonly known as castor oil plant, is used as a traditional natural remedy or folkloric herb for the control and treatment of a wide range of diseases around the globe. Various studies have revealed the presence of diverse phytochemicals such as alkaloids, flavonoids, terpenes, saponins, phenolic compounds such as kaempferol, gallic acid, ricin, rutin, lupeol, ricinoleic acid, pinene, thujone and gentisic acid. These phytochemicals have been responsible for pharmacological and therapeutic effects, including anticancer, antimicrobial, insecticidal, antioxidant, anti-diabetic, antinociceptive, anti-inflammatory, bone regenerative, analgesic, and anticonvulsant activity. R. communis harbours phytochemicals which have been shown to target peroxisome proliferator activated receptor (PPAR), nuclear factor NF- κ -B, cytochrome p450, P38 mitogen-activated protein kinases kinase (p38 MAPK), tumor protein P53, B-cell lymphoma-extra-large (Bcl-xL) and vascular endothelial growth factor receptor-2 (VEGFR-2). Considering its wide variety of phytochemicals, its pharmacological activity and the subsequent clinical trials, R. communis could be a good candidate for discovering novel complementary drugs. Further experimental and advanced clinical studies are required to explore the pharmaceutical, beneficial therapeutic and safety prospects of R. communis with its phytochemicals as a herbal and complementary medicine for combating various diseases and disorders.