Research advances on the role and mechanism of microRNA in hypertrophic scar.
10.3760/cma.j.cn501225-20220508-00179
- VernacularTitle:微小RNA在增生性瘢痕中的作用及其机制研究进展
- Author:
Wen Rong TIAN
1
;
Jun ZUO
1
;
Jiang AI
1
;
Yu Song QI
1
;
Pan Pan BU
1
;
Jiao Jun ZHAO
1
;
Yang YU
1
;
Shao Lin MA
1
Author Information
1. Department of Plastic Surgery, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China.
- Publication Type:Journal Article
- MeSH:
Humans;
MicroRNAs/genetics*;
Cicatrix, Hypertrophic/genetics*;
Fibroblasts;
Hyperplasia
- From:
Chinese Journal of Burns
2023;39(2):196-200
- CountryChina
- Language:Chinese
-
Abstract:
Hypertrophic scar (HS) affects the function and beauty of patients, and brings a heavy psychological burden to patients. However, the specific pathogenesis mechanism of HS in molecular biology level is not yet clear, and this disease is still one of the clinical diseases difficult to prevent and cure. MicroRNA (miR) is a family of single-stranded endogenous noncoding RNAs that can regulate gene expression. The abnormal transcription of miR in hypertrophic scar fibroblasts can affect the transduction and expression of downstream signal pathway or protein, and the exploration of miR and its downstream signal pathway and protein helps deeply understand the occurrence and development mechanism of scar hyperplasia. This article summarized and analyzed how miR and multiple signal pathways involve in the formation and development of HS in recent years, and further outlined the interaction between miR and target genes in HS.
