Applicability of Seven Glomerular Filtration Rate Evaluation Formulas in Dose Adjustment of High Concentration of Methotrexate Chemotherapy in Children with ALL.
10.19746/j.cnki.issn.1009-2137.2023.01.044
- Author:
Fei LI
1
;
Shan HUANG
1
;
Xia-Xia ZHU
1
;
Jing-Miao ZHANG
1
;
Hong CHEN
1
;
Xiu-Xia LIU
1
;
Qing-Mei DENG
2
,
3
Author Information
1. Department of Nuclear Medicine, The Second Hospital of Anhui Medical University, Hefei 230601, Anhui Province, China.
2. Department of Laboratory Medicine, Cancer Hospital of Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, Anhui Province, China,E-mail: okybf@
3. com.
- Publication Type:Journal Article
- Keywords:
acute lymphoblastic leukemia;
children;
glomerular filtration rate;
serum creatinine;
serum cystatin C
- MeSH:
Adolescent;
Humans;
Male;
Child;
Child, Preschool;
Glomerular Filtration Rate;
Methotrexate;
Creatinine;
Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy*;
Renal Insufficiency, Chronic/diagnosis*
- From:
Journal of Experimental Hematology
2023;31(1):280-286
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the diagnostic efficacy of seven glomerular filtration rate (GFR) evaluation formulas Schwartz2009, Schwartz1976, Counahan-Barratt, Filler, CKD-EPIscysc, Cockrofi-Gault, CKD-EPIScysC-Scr in high concentration of methotrexate (HDMTX) chemotherapy dose adjusted cut-off point (GFR ≤85 ml/min) in children with acute lymphoblastic leukemia (ALL).
METHODS:One hundred and twenty-four children with ALL were included in the study. GFR determined by renal dynamic imaging (sGFR) was used as the standard to evaluate the accuracy, consistency of eGFR calculated by seven formulas and sGFR, and the diagnostic efficacy of each formula when the sGFR ≤85 ml/min boundary.
RESULTS:All of the accuracy of eGFR estimated by Schwartz2009 were greater than 70% in the 0-3, >4 and ≤6, >6 and ≤9, >9 and ≤16 years old group and male group, and the consistency exceeded the professional threshold. When the sensitivity of the ROC curve sGFR ≤85 ml/min was 100% of CKD-EPIscysc in the 0-3, >3 and ≤4 years old group, Filler in the >3 and ≤4 years old group, and Cockrofi-Gault in the >6 and ≤9 years old group, the specificity was 73.02%, 78.95%, 78.95%, 69.32%, respectively, and the AUC under the ROC curve was the largest (P<0.05).
CONCLUSION:Schwartz2009 formula predicts the highest accuracy of eGFR in the 7 glomerular filtration rate. CKD-EPIscysc, Filler, and Cockrofi-Gault formulas have more guiding signi-ficance for the adjustment of HDMTX chemotherapy in pre-adolescence in children with ALL when sGFR ≤85 ml/min.
