Regulation of ischemic stroke by circadian rhythm and intervention by traditional Chinese medicine.
10.19540/j.cnki.cjcmm.20221019.601
- Author:
Zhong LI
1
;
Li-Juan LIU
1
;
Si-Yang YAN
1
;
Xiao-Feng GAO
1
;
Fu-Kang ZENG
2
;
De-Sheng ZHOU
1
;
Yu-Xing ZHANG
2
Author Information
1. Department of Neurology, the First Hospital of Hunan University of Chinese Medicine Changsha 410000, China.
2. Graduate School, Hunan University of Chinese Medicine Changsha 410000, China.
- Publication Type:Journal Article
- Keywords:
circadian rhythm;
ischemic stroke;
molecular mechanism;
traditional Chinese medicine
- MeSH:
Animals;
Ischemic Stroke;
Medicine, Chinese Traditional;
Circadian Rhythm;
Blood Coagulation;
Blood Pressure;
Mammals
- From:
China Journal of Chinese Materia Medica
2023;48(3):569-578
- CountryChina
- Language:Chinese
-
Abstract:
Circadian rhythm is an internal regulatory mechanism formed in organisms in response to the circadian periodicity in the environment, which modulates the pathophysiological events, occurrence and development of diseases, and the response to treatment in mammals. It significantly influences the susceptibility, injury, and recovery of ischemic stroke, and the response to therapy. Accumulating evidence indicates that circadian rhythms not only regulate the important physiological factors of ischemic stroke events, such as blood pressure and coagulation-fibrinolysis system, but also participate in the immuno-inflammatory reaction mediated by glial cells and peripheral immune cells after ischemic injury and the regulation of neurovascular unit(NVU). This article aims to link molecular, cellular, and physiological pathways in circadian biology to the clinical consequences of ischemic stroke and to illustrate the impact of circadian rhythms on ischemic stroke pathogenesis, the regulation of NVU, and the immuno-inflammatory responses. The regulation of circadian rhythm by traditional Chinese medicine is reviewed, and the research progress of traditional Chinese medicine intervention in circadian rhythm is summarized to provide a reasonable and valuable reference for the follow-up traditional Chinese medicine research and molecular mechanism research of circadian rhythm.
