Research Progressin the Relationship between Interleukin-6 and Intervertebral Disc Degeneration.
10.3881/j.issn.1000-503X.14709
- Author:
Jin-Lei CHEN
1
;
Shuang WANG
2
;
Ming-Chuan WANG
1
;
Xin WANG
1
Author Information
1. The First Clinical Medical School of Lanzhou University,Lanzhou 730000,China.
2. School of Public Health,Lanzhou University,Lanzhou 730000,China.
- Publication Type:Journal Article
- Keywords:
inflammatory responses;
interleukin-6;
intervertebral disc degeneration
- MeSH:
Humans;
Interleukin-6;
Intervertebral Disc Degeneration;
Quality of Life;
Peptides
- From:
Acta Academiae Medicinae Sinicae
2023;45(1):134-142
- CountryChina
- Language:Chinese
-
Abstract:
Intervertebral disc degeneration (IDD) is one of the main diseases causing low back pain,which seriously affects the quality of life of patients.Recent studies have discovered that interleukin-6 (IL-6) is highly expressed in the tissues and cells of degenerative intervertebral disc and is closely related to the occurrence and development of IDD.However,the signaling pathway and role of IL-6 in IDD remain to be understood.Therefore,this article reviews the recent studies about the signaling pathway and role of IL-6 in IDD,aiming to facilitate the clinical work and subsequent research progress.
