Impact of individual and combined assessment of age- and sex-specific brachial-ankle pulse wave velocity and pulse pressure on all-cause mortality.
10.3760/cma.j.cn112148-20230117-00033
- VernacularTitle:性别、年龄相关的臂踝脉搏波传导速度和脉压对全因死亡的单独及联合作用
- Author:
Zhi Wei CAO
1
;
Xu HAN
2
;
Jing LI
1
;
Jing ZHANG
1
;
Mei Ling JI
1
;
Li Wei LIU
1
;
Hai Yan ZHAO
3
;
Yun Tao WU
3
Author Information
1. Department of Cardiology, Luanzhou People's Hospital, Luanzhou 063700, China.
2. Graduate School, North China University of Science and Technology, Tangshan 063000, China Department of Cardiology, Kailuan General Hospital, Tangshan 063000, China.
3. Department of Cardiology, Kailuan General Hospital, Tangshan 063000, China.
- Publication Type:Journal Article
- MeSH:
Male;
Female;
Humans;
Blood Pressure;
Ankle Brachial Index;
Prospective Studies;
Pulse Wave Analysis;
Ankle;
Vascular Stiffness;
Risk Factors
- From:
Chinese Journal of Cardiology
2023;51(3):296-302
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the impact of individual and combined assessment of age- and sex-specific brachial-ankle pulse wave velocity (baPWV) and pulse pressure (PP) on all-cause mortality. Methods: This study is a prospective cohort study. Individuals participated in the Kailuan Study and completed baPWV measurements between 2010 and 2016 were included in this study. After stratifying by sex, 75th percentile baPWV and PP values for different age group were calculated at five years interval. BaPWV and PP values below the 75th percentile were defined as normal, and those above or equal to the 75th percentile were defined as increased. The participants were allocated to four groups according to their PP and baPWV status: normal baPWV/PP group, high baPWV/normal PP group, normal baPWV/high PP group and high baPWV/PP group. The primary outcome was all-cause mortality during the follow-up period. Cox proportional hazards models were used to explore the impact of individual and combined assessment of baPWV and PP on all-cause mortality events. Results: A total of 39 339 participants were enrolled in this study, aged (49.3±12.8) years, of which 28 731 (73.03%) were males. There were 23 268, 6 025, 6 210 and 3 836 cases in the normal baPWV/PP group, high baPWV/normal PP group, normal baPWV/high PP group and high baPWV/PP group, respectively. The average follow-up duration was (4.98±2.53) years. During the follow-up period, all-cause mortality occurred in 998 individuals. Multivariate Cox regression analysis showed increased risk of all-cause mortality in the high baPWV/normal PP group (HR=1.27, 95%CI 1.07-1.50), and in the high baPWV/PP group (HR=1.33, 95%CI 1.08-1.65) compared to the normal baPWV/PP group. Increased pulse pressure alone had no impcat on all-cause death (HR=1.06, 95%CI 0.87-1.29). Conclusions: The risk of all-cause mortality significantly increases with increased age-and sex-specific baPWV and PP values. BaPWV may be a better predictor of all-cause mortality than PP in this cohort.
