Research progress on an autophagy-mediating AMPK pathway involving bone metabolism-related cells that regulate bone homeostasis in periodontitis
10.12016/j.issn.2096-1456.2023.07.011
- Author:
LI Yanjie
1
,
2
;
LIU Wang
3
;
HE Hongbing
1
,
2
Author Information
1. Department of Periodontics, Kunming Medical University School and Hospital of Stomatology
2. Yunnan Key Laboratory of Stomatology
3. Department of Periodontics, Kunming Medical University School and Hospital of Stomatology 2 Yunnan Key Laboratory of Stomatology.
- Publication Type:Review
- Keywords:
AMP-activated protein kinase;
osteoclasts;
osteoblasts;
periodontitis;
autophagy;
bone metabolism;
bone resorption;
bone reconstruction;
differentiation;
apoptosis
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2023;31(7):524-528
- CountryChina
- Language:Chinese
-
Abstract:
Osteoclasts are the only cells responsible for bone resorption in the body, and osteoblasts are the main cells responsible for bone regeneration in the body. Under physiological conditions, these cells maintain a dynamic balance to maintain bone homeostasis. It was widely believed that the imbalance of bone metabolism is mainly affected by the expression of related inflammatory factors. However, with the gradual expansion of related studies in recent years, autophagy has been shown to be closely related to the differentiation, apoptosis and functions of osteoclasts and osteoblasts. AMP-activated protein kinase (AMPK) is an important regulator of energy metabolism in vivo and is involved in the regulation of autophagy and bone homeostasis in bone metabolism-related cells. Periodontitis is a chronic infectious disease, and its typical symptoms are alveolar bone resorption. At present, controlling the level of periodontal inflammation and alveolar bone resorption more effectively in clinical practice remains a challenge. The detection of AMPK and autophagy levels in bone metabolism-related cells shows certain prospects for the clinical prevention and treatment of periodontitis in the future. Therefore, this article reviews the regulation of periodontal inflammation levels and bone homeostasis through cell autophagy related to AMPK-mediated bone metabolism.
- Full text:AMPK通路介导骨代谢相关细胞自噬调控牙周炎骨稳态的研究进展.pdf
