Research progress of cyclic peptide synthesis strategy and its application in new drug development
10.16438/j.0513-4870.2022-0956
- VernacularTitle:环肽合成策略及其在新药研发中的应用研究进展
- Author:
Si-jia SU
1
;
Qing-wei BU
1
;
Chun-quan SHENG
2
;
Shan-chao WU
3
Author Information
1. School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China
2. School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China; Second Military Medical University, Shanghai 200433, China
3. Second Military Medical University, Shanghai 200433, China
- Publication Type:Research Article
- Keywords:
peptide;
cyclic peptide;
synthetic strategy;
improve property;
biological activity
- From:
Acta Pharmaceutica Sinica
2023;58(3):629-638
- CountryChina
- Language:Chinese
-
Abstract:
Protein-protein interaction (PPI) plays an important role in the regulation of life. Most of the PPI interfaces are large and discontinuous, and it is difficult for small molecules to specifically bind to them. Peptides are critical in PPI surface interactions due to their higher affinity and specificity. However, peptides have some defects such as easy hydrolysis by protease and poor membrane permeability. Due to good biocompatibility and chemical diversity, cyclic peptides play an important role in drug discovery. Therefore, the development of efficient cyclic peptide construction methods has become a frontier issue in peptide drug research. In recent years, a series of new progresses have been made in the synthesis strategy and the application of cyclic peptides, providing powerful technical tools for the research and development of cyclic peptide drugs. In this review, the synthesis strategies of cyclic peptides and their application will be reviewed from four aspects: synthesis strategies, property improvement, biological activity and prospect.
