Research progress on multi-target regulation strategies of tumor microenvironment based on nano-drug delivery system
10.16438/j.0513-4870.2022-0939
- VernacularTitle:基于纳米递药系统的肿瘤微环境多靶点调控策略研究进展
- Author:
Jing LI
1
;
Ting PAN
1
;
Si-yao ZHAO
1
;
Xiao-qing CHEN
1
;
Hao-tian YIN
1
;
Xiao-ye JI
1
;
Qi-fan WU
1
;
Wei WANG
1
Author Information
1. Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 210098, China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210098, China
- Publication Type:Research Article
- Keywords:
tumor microenvironment;
nanotechnology;
regulation;
targeting;
tumor therapy
- From:
Acta Pharmaceutica Sinica
2023;58(3):536-549
- CountryChina
- Language:Chinese
-
Abstract:
Tumor microenvironment (TME) is composed of endothelial cells, pericytes, immune cells, cancer-associated fibroblasts (CAFs), cancer stem cells (CSCs), extracellular matrix (ECM) and other components of the complex biological environment. TME interacts with the tumor cells through a large amount of signaling pathways, participates in the process of tumor progression, invasion, and metastasis. Hence, TME has become a potential therapeutic target for cancer treatment, exhibiting excellent therapeutic potential and research value in the field of cancer treatment. Currently, the novel nanotechnology has been widely applied in anticancer therapy, and nanotechnology-mediated drug delivery system is being explored to apply in TME modulation to inhibit tumor progression. Nanotechnology-mediated drug delivery has many advantages over traditional therapeutic modalities, including longer circulation times, improved bioavailability, and reduced toxicity. This review summarized the research of targeted nano-drug delivery based on TME regulation, including regulation strategies based on CSCs, CAFs, immune cells, ECM, tumor vascularization, exosomes, and microbiota. In addition, we summarized the advantages, opportunities, and challenges of TME regulation strategy compared with traditional treatment strategy, which provides a reference for the application of nano-drug delivery system based on TME regulation strategy in tumor precision therapy.
