Analysis of chemical components of Shenqi tiaoshen formula
- VernacularTitle:参芪调肾方的化学成分分析
- Author:
Dandan YIN
1
;
Qinjun YANG
2
;
Zegeng LI
3
Author Information
1. Dept. of Pharmacy，the First Affiliated Hospital of Anhui Medical University，Hefei 230022，China;Grade 3 Pharmaceutical Chemistry Laboratory，State Administration of Traditional Chinese Medicine，Hefei 230022，China
2. Dept. of Respiratory，the First Affiliated Hospital of Anhui University of Chinese Medicine，Hefei 230031，China;Institute of Traditional Chinese Medicine Respiratory Disease Prevention and Control，Anhui Academy of Traditional Chinese Medicine，Hefei 230031，China
3. Dept. of Respiratory，the First Affiliated Hospital of Anhui University of Chinese Medicine，Hefei 230031，China
- Publication Type:Journal Article
- Keywords:
Shenqi tiaoshen formula;
chemical components;
UPLC-QE-MS;
structure identification
- From:
China Pharmacy
2023;34(6):666-670
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To analyze chemical components of Shenqi tiaoshen formula （SQTS）. METHODS UPLC-QE-MS method was adopted. The determination was performed on ACQUITY UPLC BEH C18 column with mobile phase consisted of 0.1% formic acid solution-0.1% formic acid acetonitrile solution （gradient elution） at the flow rate of 0.4 mL/min. The column temperature was set at 40 ℃ ， and the sample size was 5 μL. The electrospray ionization source was used to scan positive and negative ions， and the scanning range was m/z 100-1 500. Combined with TCMSP， PubChem and other databases， SQTS active component database was established and the components were identified in combination with relevant literature. RESULTS & CONCLUSIONS Totally 131 chemical components were identified from SQTS， including 23 terpenoids， 22 flavonoids， 21 phenylpropanoids， 12 alkaloids， 11 phenols， 9 amino acid derivatives， 4 fatty acyls， 3 organic acids and others， such as rutin， citrinin， synephrine， cinnamic acid and ginsenoside Rg1，etc. The cracking process of the main components involved the breaking of glycosidic bonds， dehydration， etc.
