Meanings of polysaccharides in traditional Chinese medicines decoction from the viewpoint of its gut microbiota regulation effects
10.16438/j.0513-4870.2022-0861
- VernacularTitle:从肠道菌群调控角度探讨中药汤剂中多糖组分存在的意义
- Author:
Hong SHEN
1
;
Cheng-ying WU
1
;
Fang LONG
1
;
Jing ZHOU
1
;
Shan-shan ZHOU
1
;
Jun XU
2
;
Song-lin LI
1
Author Information
1. Department of Pharmaceutical Analysis and Metabolomics, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China
2. School of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China
- Publication Type:Research Article
- Keywords:
ecoction;
polysaccharide;
gut microbiota;
traditional Chinese medicine;
rug development
- From:
Acta Pharmaceutica Sinica
2022;57(12):3480-3486
- CountryChina
- Language:Chinese
-
Abstract:
Decoction is one of the traditional dosage forms of traditional Chinese medicines (TCMs). In addition to small molecular components, decoction also contains polysaccharides and other macromolecular components. For a long time, ethanol precipitation has been commonly used during TCMs based new drug development to remove "ineffective macromolecular components", and enrich "active small molecules components", so as to improve the subsequent formability of the preparations. With the recognition of the relationships between gut microbiota and host health/disease, and the potential prebiotic effects of natural polysaccharides, the important values of polysaccharides in TCMs decoctions have been gradually emerged. Based on the representative findings of our own research and the literatures, the potential prebiotics function of TCMs polysaccharides were reviewed regarding its related effects on host physiological and pathological processes of metabolic function, bowel function, immunity, inflammation, emotion and tumor, on the metabolism and absorption of coexisting small molecule components, as well as the structure-function features, so that the meanings of polysaccharides in TCMs decoction were discussed and emphasized, and hopefully to provide enlightenment for the premise of attaching importance to the existence of polysaccharide components in the process of innovative drug research and development based on classical and clinical TCMs prescriptions.
