Vascularization of intravitreal injection of Conbercept in the treatment of retinopathy of prematurity
- VernacularTitle:玻璃体内注射康柏西普治疗早产儿视网膜病变的血管化过程
- Author:
Zheng FU
1
;
Wei-Wei XIONG
1
;
Xue YIN
1
;
Zhi-Bin HONG
1
;
Xiu-Ting LI
1
;
Xi-Xiang WEI
1
;
Wei-Fang FANG
1
;
Ya-Juan CHEN
1
;
Jing-Wei LIN
1
;
Yan-Hui ZHU
1
;
Yi-Hua ZHU
1
;
Hui YANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Conbercept; retinopathy of prematurity; vascularization
- From: International Eye Science 2023;23(3):363-368
- CountryChina
- Language:Chinese
- Abstract: AIM: To evaluate retinal vascularization caused by the intravitreal injection of Conbercept in the treatment of a series of retinopathy of prematurity(ROP)cases in Type Ⅰ(threshold and pre-threshold period)and aggressive ROP(A-ROP).METHODS: The data of 34 ROP cases(67 eyes)treated by intravitreal injection of Conbercept(IVC)in the ophthalmology department of the Xiamen Children's Hospital from July 2017 to March 2020 were retrospectively analyzed. Reactivation, which refers to recurrence of acute phase features, occurred at any stage of the disease in the presence or absence of other diseases. RESULT: The average gestational age of the 34 children was 28.82±2.32wk. The average birth weight was 1155.18±398.22g. The lesion zone of 19 cases(37 eyes)was Zone Ⅰ. In 10 cases(20 eyes), the lesion was in Zone Ⅱ, and in 5 cases(10 eyes), the lesion was in the posterior Zone Ⅱ. The total effective rate of disease control in ROP children treated with once IVC was 73.1%(49/67), and the vascularization of Zone Ⅱ was completed. The patients showed variable changes in the vascularization in Zone Ⅲ. For the patients who received one treatment and did not reactivate, the average rate of Type Ⅰ vascularization of ROP was 9.11±2.49wk, and the A-ROP was 13.40±4.04wk. The rate of A-ROP vascularization in Zone Ⅱ was significantly longer compared to Type Ⅰ.CONCLUSION: IVC effectively completes vascularization in Zone Ⅱ.
