Association between serum 25-hydroxyvitamin D and thyroid autoantibodies and thyroid nodules in women for health examination in Shanghai
10.19428/j.cnki.sjpm.2022.22149
- VernacularTitle:上海某院体检女性血清25羟维生素D与甲状腺自身抗体及甲状腺结节间的关系
- Author:
Yumei WU
1
;
Yonghui GAO
1
Author Information
1. Huadong Sanatorium， Wuxi， Jiangsu 214065， China
- Publication Type:Journal Article
- Keywords:
25-hydroxyvitamin D;
anti-thyroglobulin antibody;
anti-thyroid peroxidase autoantibody;
female;
thyroid nodule
- From:
Shanghai Journal of Preventive Medicine
2022;34(12):1229-1233
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo determine the level of serum 25-hydroxyvitamin D （25（OH）D） and its association with thyroid autoantibodies and thyroid nodules in adult women for health examination in Shanghai. MethodsWe recruited a total of 2 108 healthy women for examination in the hospital. According to the serum 25-hydroxyvitamin D， the women were classified into four groups： 25（OH）D≥30 μg·L-1 as sufficient group， 20 μg·L-1≤25（OH）D<30 μg·L-1 as insufficient group， 10 μg·L-1≤25（OH）D<20 μg·L-1 as the deficiency group， and<10 μg·L-1 as severe deficiency group. The association was determined between the serum 25（OH）D and thyroid autoantibodies and thyroid nodules. ResultsThe prevalence of deficiency in adult women was determined to be 69.31%. Alkaline phosphatase （ALP）， low-density lipoprotein （LDL）， anti-thyroglobulin antibodies （TGAB） and anti-thyroid peroxidase autoantibody （TPOAB） levels significantly differed between the severe deficiency group and sufficient group （each P<0.05）. Moreover， prevalence of thyroid nodules， TGAB， TGAB and/or TPOAB differed significantly across the four groups （each P<0.05）. Logistic regression analysis showed that decrease of serum 25（OH）D was significantly associated with age and increasing prevalence of thyroid nodules， TGAB， TGAB and/or TPOAB. ConclusionVitamin D deficiency remains high in adult women for health examination in Shanghai. Serum 25（OH）D insufficiency or deficiency is associated with age， thyroid autoantibodies and thyroid nodules.
