Ovarian new growth in progeria.
- Author:
Cherise Andrea E. Llaneta
;
April Grace Berboso
;
Maria Therese B. Mallen
- Publication Type:Case Reports
- From:
The Philippine Children’s Medical Center Journal
2021;17(2):51-59
- CountryPhilippines
- Language:English
-
Abstract:
The Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disease that involves singlebase gene mutation in the LMNA gene which results in the production of a dysfunctional and
mutant lamin A protein called progerin. Progerin is found in increased concentration in normal
older individuals hence patients present with phenotypic signs of aging. [1] Based on current
studies, there is no established predisposition and association between abdominal masses,
specifically ovarian masses in female, adolescent, progeria patients.
This is an adolescent female patient with progeria presenting with an ovarian mass. Further
studies to establish the correlation between Hutchinson-Gilford progeria syndrome (HGPS) and
abdominal masses specifically masses in the reproductive system have yet to be done. The exact
mechanism by which progeria patients become predisposed to developing abdominal masses,
specifically ovarian masses is still a grey area in research. Through this case report, routine
abdominal ultrasound screening or routine abdominal CT scan can be done to screen for presence
of masses in HGPS patients.
- Full text:Ovarian new growth in progeria..pdf
