Role of extracellular vesicles in the diagnosis and therapy of kidney disease: opportunities and challenges
10.3760/cma.j.cn114452-20220517-00295
- VernacularTitle:细胞外囊泡在肾脏疾病诊断和治疗中的机遇与挑战
- Author:
Jie GAO
1
;
Haixia LI
Author Information
1. 山西白求恩医院（山西医学科学院同济山西医院）检验科，山西医科大学第三医院，太原 030032
- Keywords:
Extracellular vesicles;
Kidney disease;
Diagnosis;
Therapy
- From:
Chinese Journal of Laboratory Medicine
2022;45(7):665-670
- CountryChina
- Language:Chinese
-
Abstract:
Extracellular vesicles (Evs) are important vectors for cell-cell communication and their potential value in the diagnosis and treatment of kidney diseases has been explored. Recent studies have revealed that changes in the level and characteristics of urinary extracellular vesicles from resident kidney cells are related to severity of various kidney diseases. Yet, circulating extracellular vesicles may also be altered in kidney disease. Circulating EVs and urinary EVs secreted by renal cells have been shown as potential early biomarkers of renal injury. EVs derived from repair cells such as mesenchymal stem cells also represent promising therapeutic agents for treatment of kidney diseases. Furthermore, engineered extracellular vesicles are being developed for specific therapy of certain kidney diseases. In conclusion, EVs may represent promising biomarkers for the detecting and monitoring of renal diseases, which has also the potential to be used as diagnostic and therapeutic tools. This review focuses on the utility of extracellular vesicles as therapeutic and diagnostic tools in kidney diseases and future prospective of EVs research.
