The role of extracellular vesicles in human cytomegalovirus infection
10.3760/cma.j.cn114452-20220216-00076
- VernacularTitle:细胞外囊泡在人巨细胞病毒感染中的作用
- Author:
Huamei LI
1
;
Lin HE
;
Ran TAO
;
Shiqiang SHANG
Author Information
1. 浙江大学医学院附属儿童医院实验检验中心 国家儿童健康与疾病临床医学研究中心 国家儿童区域医疗中心，杭州310000
- Keywords:
Cytomegalovirus;
Extracellular vesicle;
Infection
- From:
Chinese Journal of Laboratory Medicine
2022;45(6):656-660
- CountryChina
- Language:Chinese
-
Abstract:
Extracellular vesicles (EV) are membrane structured vesicles containing proteins, lipids and nucleic acids. EVS produced by virus-infected cells are involved in communication between infected and uninfected cells. EV produced by human cytomegalovirus (HCMV) infected cells can promote the transmission and infection of HCMV and escape the host immune response. It can also activate the body′s immune response against HCMV infection. In-depth study of the mechanism and compositional changes of EV produced by HCMV infected cells will contribute to the prevention, diagnosis, and treatment of HCMV. The current research has achieved some results, but they are not deep enough. Future advancements in EV isolation and identification technologies and the reduction of economic costs will contribute to the extensive development and clinical application of the research.
