Advances and utility of laboratory investigation in diagnosis of pediatric allergic diseases
10.3760/cma.j.cn114452-20220118-00025
- VernacularTitle:儿童过敏性疾病实验室诊断与应用
- Author:
Shaohua HU
1
;
Sijian WANG
;
Hong ZHANG
Author Information
1. 上海市儿童医院 上海交通大学医学院附属儿童医院检验科，上海 200062
- Keywords:
Children;
Allergic diseases;
Laboratory diagnosis;
Allergens
- From:
Chinese Journal of Laboratory Medicine
2022;45(6):568-573
- CountryChina
- Language:Chinese
-
Abstract:
The rapid increase of childhood allergic disorders has become one of the major challenges in the pediatric health care system. Laboratory diagnosis is essential in order to determine appropriate strategies towards best clinical practice strategies, including accurate diagnosis, prophylaxis and optimized management. Once there are sufficient clinical grounds to support a diagnosis of allergy, confirmatory in vivo and in vitro tests should be performed. In vivo tests mainly include skin prick tests and allergen provocation tests. Provocation tests are the gold standard for diagnosing allergic diseases. In vitro tests mainly include allergen-specific IgE antibody, Th2 related cytokines, and mast cell activity markers. These tests can clarify the immune state status of the patient and lead to optimized treatment, such as avoiding allergens avoidance, allergens-specific immunotherapy, and anti-IgE therapy. Controlling disease progress and preventing relapses can benefit children who are suffering from the consequences of allergies.
