Progress in signaling pathways related to the fibrosis mechanism in systemic sclerosis
10.3760/cma.j.cn112309-20220117-00013
- VernacularTitle:系统性硬化症纤维化机制相关信号通路的研究进展
- Author:
Baoyue WANG
1
;
Yongfu WANG
;
Xiaolin SUN
Author Information
1. 包头医学院第一附属医院中心实验室（内蒙古自治区自体免疫学重点实验室），包头 014010
- Keywords:
Systemic sclerosis;
Fibrosis;
Signaling pathway;
Treatment
- From:
Chinese Journal of Microbiology and Immunology
2022;42(10):824-830
- CountryChina
- Language:Chinese
-
Abstract:
Systemic sclerosis (SSc) is a complex and chronic autoimmune disease causing fibrosis in multiple tissues and organs. The cause of fibrosis may be related to the production of extracellular matrix (ECM) such as type Ⅰ and Ⅲ collagens, elastin and fibronectin resulting from the transformation of activated fibroblasts (FB) into muscle-forming fibroblasts (MFB). ECM could seriously damage the skin, lung, heart, kidney and other organs. At present, many studies have shown that several signaling pathways including TGF-β, mTOR, JAK/STAT, Wnt/β-Catenin, Hedgehog and Notch are involved in the proliferation of FB and the transformation of FB to MFB, which led to the production and deposition of a great quantity of ECM. Therefore, this article reviewed the relationship between these signaling pathways and fibrosis in SSc, hoping to provided reference for the development of effective treatments for SSc.
