Research progress in human cytomegalovirus and its association with TGF-β and Smad signaling pathway
10.3760/cma.j.cn112309-20211102-00365
- VernacularTitle:人巨细胞病毒与TGF-β及Smad信号通路相关性的研究进展
- Author:
Lin LI
1
;
Shiqiang SHANG
Author Information
1. 浙江大学医学院附属儿童医院实验检验中心，杭州 310052
- Keywords:
Human cytomegalovirus;
TGF-β;
Smad signaling pathway;
Infection
- From:
Chinese Journal of Microbiology and Immunology
2022;42(6):490-494
- CountryChina
- Language:Chinese
-
Abstract:
Human cytomegalovirus (HCMV) is a common herpes virus found in human and can establish lifelong latency in the hosts. In healthy population, HCMV usually results in asymptomatic latent infection. However, the latent HCMV can be activated and cause many serious diseases and even death in people with low immunity. Transforming growth factor-β (TGF-β) is a powerful regulator of many cellular pathways, playing important roles in inflammatory response and cell differentiation, as well as immunomodulatory role in viral infection. The classic Smad signaling pathway is involved in the regulation of many cell activities, including growth, differentiation and apoptosis. This review summarized the progress in the association of HCMV infection with TGF-β and the Smad signaling pathway.
