Vacuoles in muscle fiber: pathological differences in various diseases
10.3760/cma.j.cn113694-20220211-00093
- VernacularTitle:空泡性肌纤维：不同疾病的病理差异
- Author:
Chang LIU
1
;
Wei ZHANG
;
Zhaoxia WANG
;
Yun YUAN
Author Information
1. 北京大学第一医院神经内科，北京100034
- Keywords:
Vacuoles;
Myopathy;
Autophagy;
Muscle biopsy
- From:
Chinese Journal of Neurology
2022;55(11):1317-1324
- CountryChina
- Language:Chinese
-
Abstract:
The vacuole in muscle fibers is a non-specific myopathological change. As a myopathological term, it occurs in several rare disorders. The vacuoles are mostly related to the autophagy of glycogen, lipids, abnormal proteins, and organelles, and a few are caused by glycogen or lipids deposition or sarcoplasmic reticulum luminal vacuolization. The vacuoles impair the structure of muscle fibers, being one of the myopathological features in various diseases. In this review, clinical features and myopathological changes of various diseases with vacuolar muscle fibers were introduced and the diagnostic value of intrafibral vacuoles was focused on. Knowing the underlying pathogenesis is required to understand these myopathological changes.
