Research progress on single-molecule array technology-based blood neuronal markers for Alzheimer's disease
10.3760/cma.j.issn.0254-9026.2022.11.025
- VernacularTitle:基于单分子阵列技术的阿尔茨海默病血液神经标志物的研究进展
- Author:
Liya TIAN
1
;
Weihua LIU
Author Information
1. 山东第一医科大学(山东省医学科学院)神经内科 护理学院，济南 250000
- Keywords:
Alzheimer's disease;
Biological markers;
Single-molecule Array
- From:
Chinese Journal of Geriatrics
2022;41(11):1400-1404
- CountryChina
- Language:Chinese
-
Abstract:
Early detection and intervention is an important strategy for the prevention and treatment of Alzheimer's disease(AD). Blood screening for AD has advantages such as low cost and convenient sample collection.However, there are also problems such as low levels of markers in peripheral blood and insufficient sensitivity of detection methods.At present, as a highly sensitive detection technology for protein molecules, single-molecule array(Simoa)technology can accurately analyze low-concentration biomarkers that cannot be detected by traditional methods.This article reviews research progress on blood neuronal markers for early AD diagnosis based on the new Simoa technology.
