Whether radiotherapy for pelvic tumor increases the risk of second primary cancer

VernacularTitle:盆腔肿瘤放疗是否增加二次肿瘤风险的探讨
Author: Yan HUANG ¹ ; Chunhua LU ; Ying ZHANG ; Qing LIN
Author Information

1. 同济大学附属第十人民医院放疗科，上海　200072
Keywords: Pelvic neoplasms; Radiotherapy; Second primary cancer
From: Chinese Journal of Radiation Oncology 2022;31(8):745-749
CountryChina
Language:Chinese
Abstract: Second primary cancer (SPC) is one of the main late toxicities of tumor therapy. According to statistics, one out of every 12 cancer survivors will develop SPC, and more than half of the cancer survivors will die of SPC. At present, approximately 70% of cancer patients receive radiotherapy (RT) throughout the course of disease. Whether high-dose radiation will increase the risk of SPC has captivated widespread attention. Among them, most pelvic tumor patients should receive RT because of the high incidence. In this article, relevant studies of potential pathogenesis of SPC, impact of different RT techniques, selection of RT timing, and RT for male, female and pediatric pelvic tumors were reviewed, aiming to investigate whether pelvic RT will increase the risk of SPC.