Anticoagulation strategy of acute portal vein thrombosis in pregnancy

VernacularTitle:妊娠合并急性门静脉血栓形成的抗凝策略
Author: Bodong XU ¹ ; Hai FENG
Author Information

1. 首都医科大学附属北京友谊医院血管外科，北京　100050
Keywords: Portal vein thrombosis; Pregnancy; Anticoagulation
From: Clinical Medicine of China 2022;38(5):394-397
CountryChina
Language:Chinese
Abstract: Portal vein thrombosis(PVT) plays a crucial role in pathogenesis of portal hypertension. Thrombus located in portal trunk or hepatic branches, which can expand into splenic vein or mesenteric vein, causing severe symptoms. Hypercoagulation state and portal haemodynamic disorder increase the risk of PVT in pregnancy. Anticoagulation is the basic treatment of pregnancy complicated with acute PVT, which can not only inhibit the progress of portal vein thrombosis, but also promote the recanalization of the lumen and improve the prognosis of patients. Anticoagulation should be administered for at least 6 moths according to available guidelines. Based on reliable efficacy and superior safety, low-molecular-weight-heparin remains the first choice of anticoagulant therapy. Vitamin K antagonists and direct oral anticoagulants are not recommended for PVT in pregnancy.