Research progress of S-nitrosoglutathione reductase inhibitors in the regulation of cerebral injury after cardiac arrest-cardiopulmonary resuscitation
10.3760/cma.j.cn121430-202100203-00198
- VernacularTitle:S-亚硝基化谷胱甘肽还原酶抑制剂调控心搏骤停-心肺复苏后脑损伤的研究进展
- Author:
Jianhong WANG
1
;
Manhong ZHOU
Author Information
1. 遵义医科大学附属医院急诊科，贵州遵义 563003
- Keywords:
Cardiac arrest;
Cardiopulmonary resuscitation;
Nitric oxide;
S-nitrosylation;
S-nitrosoglutathione reductase;
Cerebral ischemia/reperfusion injury
- From:
Chinese Critical Care Medicine
2022;34(9):995-998
- CountryChina
- Language:Chinese
-
Abstract:
The cerebral ischemia-reperfusion injury (CIRI) after the cardiac arrest (CA)-cardiopulmonary resuscitation (CPR) was a complex pathophysiology process. Nitric oxide (NO) is a small molecule that mediates cell signal transduction in vivo and plays an important role in the regulation of brain function during ischemia/reperfusion (I/R). S-nitrosoglutathione reductase (GSNOR) inhibitor can regulate the synthesis and release of NO in vivo and has a protective effect on CIRI. Therefore, early administration of GSNOR to CA-CPR patients could be the main treatment method to improve the prognosis of those patients. A large number of studies have been done to improve the prognosis of CA-CPR in recent years. In order to provide reference for further research on the treatment and brain protection of CIRI after CA-CPR, the article reviewed the main mechanisms of brain injury after CA-CPR, the protective effect and mechanism of NO on cerebral I/R injury, the production and regulation of NO, in vivo, and the protective effect of GSNOR inhibitors on CIRI, especially the research progress of GSNOR inhibitors.
