Anti-retinal antibodies and their role in autoimmune retinopathy
10.3760/cma.j.cn115989-20190708-00298
- VernacularTitle:抗视网膜抗体及其在自身免疫性视网膜病变中的作用
- Author:
Yaoyao SUN
1
;
Mingwei ZHAO
;
Huijun QI
Author Information
1. 北京大学人民医院眼科 眼视光中心 眼病与视光医学研究所 视网膜脉络膜疾病诊治研究北京市重点实验室 北京大学医学部眼视光学院，北京 100044
- Keywords:
Paraneoplastic syndromes, ocular;
Anti-retinal antibody;
Autoimmune retinopathy;
Photoreceptors
- From:
Chinese Journal of Experimental Ophthalmology
2022;40(11):1104-1107
- CountryChina
- Language:Chinese
-
Abstract:
Autoimmune retinopathy (AIR) is a group of immune-mediated retinopathies that usually results in severe loss of vision and visual field defects.AIR mainly includes paraneoplastic and non-paraneoplastic syndromes.One main feature of AIR is the presence of circulating anti-retinal antibodies (ARAs) in peripheral blood, which are produced through anti-tumor responses, anti-microbial responses, and immune responses induced by autoantigen fragments following retinal injury, and mainly attack retinal photoreceptor cells.ARAs are important for the diagnosis, progression assessment and treatment outcome of AIR.These ARAs often appear before the diagnosis of cancer and can be helpful for the early detection of malignant tumors.The mechanism of ARAs production, its pathological role in AIR, and its significance in clinical practice were reviewed in this article.
