Significance of molecular diagnostic technology in the diagnosis and treatment of inflammatory bowel disease in children
10.3760/cma.j.cn101070-20210722-00862
- VernacularTitle:分子诊断技术在儿童炎症性肠病诊治中的意义
- Author:
Jing GOU
1
;
Zhaoxia WANG
Author Information
1. 深圳市儿童医院消化内科，深圳 518038
- Keywords:
Inflammatory bowel disease;
Molecular diagnosis;
Monogenic defect;
Pharmacogenetics;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2022;37(23):1773-1776
- CountryChina
- Language:Chinese
-
Abstract:
With the development of biological technology, molecular diagnosis has been increasingly applied in clinical practice and treatment.Inflammatory bowel disease (IBD) in children is a chronic intestinal inflammation caused by infection, immunity, environment and other factors in a specific genetic background.Children with IBD, especially early-onset and very early-onset IBD, can be considered a monogenic disease.Early identification of such children in clinical work and timely improvement of gene detection can identify the types of gene defects and reveal the inflammatory signal transduction pathways, providing a theoretical basis for the selection of treatment options.Moreover, drug-related pharmacogenetics in the treatment of IBD directly affects the organism′s response rate to drugs, thereby affecting the clinical remission and intestinal mucosal repair.Therefore, the understanding of the characteristics of drug immunogenicity of the Asian population, which can reduce the unnecessary waste of medical resources, the adverse drug reactions in children during the induction and maintenance of remission and complications and recurrence rate, is of great importance.
