Advances in the classification and biological properties of streptococcal superantigens
10.3760/cma.j.cn101070-20220524-00601
- VernacularTitle:链球菌超抗原分类及其生物学作用研究进展
- Author:
Limin DONG
1
;
Kaihu YAO
Author Information
1. 国家儿童医学中心，首都医科大学附属北京儿童医院，北京市儿科研究所皮肤疾病研究室，国家呼吸系统疾病临床医学研究中心，教育部儿科重大疾病研究重点实验室，北京 100045
- Keywords:
Superantigen;
Streptococcus;
Biological properties;
Pathogenesis
- From:
Chinese Journal of Applied Clinical Pediatrics
2022;37(21):1674-1677
- CountryChina
- Language:Chinese
-
Abstract:
Superantigens are highly mitogenic exotoxins produced by bacteria and viruses.They can bind to the major histocompatibility complex class Ⅱ, stimulate T cell receptor molecules to release a large quantity of proinflammatory cytokines, and activate the immune system in vastly low concentrations.Superantigens have been the most effective T cell mitogen discovered so far.Superantigens play important roles in infection diseases caused by streptococcal pathogens, and they can facilitate pathogen colonization, proliferation, and dissemination.Further research of biological chara-cteristics of streptococcus superantigens is vital to understanding the streptococcus pathogenesis, prevention and treatment of streptococcus infection.In this article, advances in the classification, biological properties, pathogenesis, deve-lopment and application of streptococcal superantigens were reviewed, so as to improve the clinical understanding and provide reference for in-depth research of related diseases.
