Research progress of lymphoma-associated hemophagocytic syndrome in children

VernacularTitle:儿童淋巴瘤相关噬血细胞综合征的诊治研究进展
Author: Huixia GAO ¹ ; Zhigang LI ; Rui ZHANG ; Tianyou WANG
Author Information

1. 国家儿童医学中心，首都医科大学附属北京儿童医院血液肿瘤中心，儿童血液病与肿瘤分子分型北京市重点实验室，儿科学国家重点学科，儿科重大疾病研究教育部重点实验室，北京　100045
Keywords: Hemophagocytic syndrome; Lymphoma-associated hemophagocytic syndrome; Child
From: Chinese Journal of Applied Clinical Pediatrics 2022;37(18):1426-1428
CountryChina
Language:Chinese
Abstract: Hemophagocytic syndrome, also known as hemophagocytic lymphohistiocytosis (HLH), is a highly stimulated and defective inflammatory response caused by genetic inheritance or acquired immune regulation abnormalities.Lymphoma-associated hemophagocytic syndrome (LAHS) is a malignancy-associated HLH secondary to lymphoma, with a high clinical misdiagnosis rate and fatality rate and poor prognosis.In this article, the pathogenesis, diagnosis and treatment of LAHS in children were reviewed, in order to increase clinician′s understanding of the disease.