Research progress of respiratory microecology and bronchopulmonary dysplasia
10.3760/cma.j.cn101070-20210623-00718
- VernacularTitle:呼吸道微生态与支气管肺发育不良研究进展
- Author:
Qian ZHENG
1
;
Junjie YING
;
Jing SHI
;
Dezhi MU
Author Information
1. 四川大学华西第二医院儿科，出生缺陷与相关妇儿疾病教育部重点实验室，成都 610041
- Keywords:
Respiratory microecology;
Lung development;
Bronchopulmonary dysplasia;
Probiotics
- From:
Chinese Journal of Applied Clinical Pediatrics
2022;37(15):1197-1200
- CountryChina
- Language:Chinese
-
Abstract:
Bronchopulmonary dysplasia (BPD) is a common respiratory disease in preterm infants.Infection, inflammation and oxidative stress are the main pathogenic mechanisms of BPD.Recent studies have shown that the colonization of pulmonary microorganisms begins from the perinatal period and dynamically changed by multiple factors.Respiratory microecology dysbiosis may trigger oxidative stress, inhibit the expression of miR-876-3p, change pulmonary metabolism and weaken local barrier function, thereby leading to the occurrence and progress of BPD.At the same time, abnormal pulmonary development and lung injury also exert impact on respiratory microecology, and the impact even lasts till adulthood.Probiotics have anti-inflammatory, anti-infection and antioxidant effects.Supplementation of probiotics may promote lung development and alleviate lung injury conditions by regulating respiratory microecology.In this article, the establishment and dynamic changes of neonatal respiratory microecology were elaborated, and the role of respiratory microecology in the pathogenesis, prevention and treatment of BPD was explored.
