Progress on the pathogenesis of gut microbiota in neonatal necrotizing enterocolitis
10.3760/cma.j.issn.1673-4408.2022.09.005
- VernacularTitle:肠道菌群参与新生儿坏死性小肠结肠炎发病机制的研究进展
- Author:
Xiaoyu CHEN
1
;
Yongyan SHI
Author Information
1. 中国医科大学附属盛京医院儿内科，沈阳 110004
- Keywords:
Necrotizing enterocolitis;
Neonate;
Pathogenesis;
Gut microbiota;
Dysbiosis
- From:
International Journal of Pediatrics
2022;49(9):597-601
- CountryChina
- Language:Chinese
-
Abstract:
Necrotizing enterocolitis(NEC)is an acute inflammatory disease of the intestine which is related to gut dysbiosis.Gut microbiota of NEC patients in meconium or feces are different from those of healthy infants.Although the pathogenic bacteria and metabolites of NEC have not been specified, short-chain fatty acids, lithocholic acid and tryptophan derived metabolites may play protective or aggravating roles in NEC.Probiotics and fecal microbiota transplantation that target on gut microbiota may optimize the composition of gut microbiota and thereby decrease the incidence of NEC.Besides, the early diagnosis of NEC is challenging due to its unspecific presentations.Once diagnosed, it is often severe.More research about disease biomarkers based on gut microbiota is needed.
