Myelosuppression complicated with infection after chemotherapy in children with acute myeloid leukemia
10.3760/cma.j.issn.1673-4408.2022.09.003
- VernacularTitle:儿童急性髓细胞白血病化疗后骨髓抑制期合并感染的研究进展
- Author:
Qingyuan XU
1
;
Huyong ZHENG
Author Information
1. 国家儿童医学中心 首都医科大学附属北京儿童医院 血液病中心 儿童血液病与肿瘤分子分型北京市重点实验室 儿童血液病国家临床重点专科 儿科学国家重点学科 儿科重大疾病研究教育部重点实验室 100045
- Keywords:
Children;
Acute myeloid leukemia;
Myelosuppression;
Infection;
Fever;
Neutropenia
- From:
International Journal of Pediatrics
2022;49(9):587-591
- CountryChina
- Language:Chinese
-
Abstract:
The overall survival rate of children with acute myeloid leukemia(AML) is significantly lower than that of acute lymphoblastic leukemia.The main causes of death include primary disease-related death and treatment-related death.Most of the treatment-related deaths are caused by infection, bleeding and organ failure.Infection is the most common complication of pediatric AML during the myelosuppression period after chemotherapy, and it is also the main cause of early death in AML.Based on the analysis of pathogens, laboratory tests and risk factors, this paper reviews the clinical characteristics and research progress of infection in myelosuppression following chemotherapy for AML, so as to provide a basis for early identification, clinical management and condition judgment, and further improve the survival rate of children with AML.
