Progress of the relationship between group 2 innate lymphoid cells and bronchial asthma
10.3760/cma.j.issn.1673-4408.2022.07.008
- VernacularTitle:Ⅱ型固有淋巴细胞与支气管哮喘关系的研究进展
- Author:
Yingli ZHANG
1
;
Gen LU
Author Information
1. 广州医科大学附属广州市妇女儿童医疗中心呼吸科 510120
- Keywords:
Asthma;
Group 2 innate lymphoid cells;
Pathogenesis
- From:
International Journal of Pediatrics
2022;49(7):465-469
- CountryChina
- Language:Chinese
-
Abstract:
Group 2 innate lymphoid cells (ILC2) are a newly identified subset of innate immune cells which are closely associated with the development of bronchial asthma(asthma). ILC2 develops from lymphoid progenitor cells in the bone marrow under the regulation of retinoid-related nuclear orphan receptor α (RORα) and GA-TA-binding protein-3 (GATA-3). ILC2 can be activated by IL-25, IL-33, thymic stromal lymphopoietin (TSLP) and lipid mediator and produce Th2 cytokines, such as IL-4, IL-5, IL-9 and IL-13, which activate innate immune cells and adaptive immune cells to participate in asthma inflammation.ILC2 may be a therapeutic target for asthma, providing new possibilities for the prevention and treatment.
