The effect of psychosocial stress on asthma in children and its mechanism
10.3760/cma.j.issn.1673-4408.2022.05.012
- VernacularTitle:社会心理压力对儿童哮喘的影响及机制
- Author:
Beibei ZHU
1
;
Deyu ZHAO
Author Information
1. 南京医科大学附属儿童医院呼吸内科 210000
- Keywords:
Children;
Asthma;
Psychosocial stress;
Hypothalamic-pituitary-adrenal axis;
Genetics
- From:
International Journal of Pediatrics
2022;49(5):338-342
- CountryChina
- Language:Chinese
-
Abstract:
With the development of the understanding of bronchial asthma(asthma for short) and the accumulation of diagnosis and treatment experience, people realize that asthma is a heterogeneous physical and mental disease.Psychosocial stress can increase the frequency of asthma attacks in children and increase the burden of family and society.Psychosocial stress from individual, family and other levels transduces signals in the brain, which are transmitted to downstream effectors, producing effectors such as adrenocorticosteroids, enhancing Th2 and Th17 cell responses, inhibiting Treg cell responses, and influencing specific asthma related genotypes.This paper reviews the mechanism of psychosocial stress on asthma, in order to better control and treat asthma and improve the quality of life of children with asthma.
